Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13134221 | 0.80 | GPR3 (0.44) | GPR3LMNAMEN1KMT2ABLM | |
| SCHEMBL9114832 | 0.80 | GPR3 (0.44) | GPR3LMNAMEN1KMT2ATGFBR1 | |
| SCHEMBL10738301 | 0.76 | HPGD (0.42) | GPR3LMNAMEN1KMT2ATGFBR1 | |
| SCHEMBL10738298 | 0.76 | HPGD (0.42) | GPR3LMNAMEN1KMT2ATGFBR1 | |
| SCHEMBL2491042 | 0.76 | MAPT (0.44) | GPR3LMNAMEN1KMT2AKDM4E | |
| SCHEMBL2491044 | 0.76 | MAPT (0.44) | GPR3LMNAMEN1KMT2AKDM4E | |
| SCHEMBL2008924 | 0.74 | KMT2A (0.39) | GPR3LMNAMEN1KMT2ATHRB | |
| Hydrochloric Acid SCHEMBL10842837 | 0.74 | HPGD (0.41) | GPR3LMNAMEN1KMT2ATGFBR1 | |
| SCHEMBL9111565 | 0.74 | GPR3 (0.39) | GPR3LMNAMEN1KMT2ATGFBR1 | |
| SCHEMBL276531 | 0.72 | GPR3 (0.50) | GPR3LMNAMEN1KMT2ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105246893-B | It is used as the pyrazolo benzodiazine derovatives of METAP2 (2 type methionine aminopeptidase) inhibitor | 赛诺菲 | 2017-10-27 | — | — | CN | claimed |
| CN-103687852-B | 2-amino-3-(imidazoles-2-base)-pyridin-4-one derivatives and the purposes as vegf receptor kinase inhibitor thereof | 赛诺菲 | 2016-08-17 | — | — | CN | claimed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2019-03-07 | — | — | US | disclosed |
| US-10155730-B2 | Isoxazoline derivatives as insecticides | SYNGENTA CROP PROTECTION, LLC (US) | 2018-12-18 | — | — | US | disclosed |
| CN-105377849-B | For preventing and kill off the substituted pyrimidines * compounds and derivative of animal pest | 巴斯夫欧洲公司 | 2018-01-26 | — | — | CN | disclosed |
| CN-105246893-B | It is used as the pyrazolo benzodiazine derovatives of METAP2 (2 type methionine aminopeptidase) inhibitor | 赛诺菲 | 2017-10-27 | — | — | CN | disclosed |
| CN-104602691-B | VEGFR 3 inhibitor is for treating the purposes of hepatocarcinoma | 赛诺菲 | 2016-12-28 | — | — | CN | disclosed |
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2016-12-22 | — | — | US | disclosed |
| CN-103687852-B | 2-amino-3-(imidazoles-2-base)-pyridin-4-one derivatives and the purposes as vegf receptor kinase inhibitor thereof | 赛诺菲 | 2016-08-17 | — | — | CN | disclosed |
| CN-105377849-A | Substituted pyrimidinium compounds and derivatives for combating animal pests | BASF SE | 2016-03-02 | — | — | CN | disclosed |
| US-20080004262-A1 | Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-01-03 | — | — | US | disclosed |
| CN-1889947-A | Tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents | SCHERING AG (DE) | 2007-01-03 | — | — | CN | disclosed |
| EP-1732929-A1 | TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS | Nissan Chemical Industries, Ltd. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005090357-A1 | TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-29 | — | — | WO | disclosed |
| CN-1158281-C | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | ��һ��������ҩ��ʽ���� | 2004-07-21 | — | — | CN | disclosed |
| CN-1474689-A | CDC25 phosphatase inhibitors | ��ѧ�о���Ӧ����ѯ��˾ | 2004-02-11 | — | — | CN | disclosed |
| US-6043226-A | TREATING BACTERIAL, PARASITIC AND PROTOZOAL INFECTIONS | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |
| CN-1239478-A | 1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor | SUNTORY LTD (JP) | 1999-12-22 | — | — | CN | disclosed |
| CN-1014060-B | METHOD FOR PREPARAING ORTHO-AZONAPHTHALENE COMPOUND | IMP CHEMICAL IND PAN AMERICAL (US) | 1991-09-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071407-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | GPR3 1178/4885LMNA 1648/4885MEN1 2329/4885 |
| US-10155730-B2 | Isoxazoline derivatives as insecticides | ACHE, CHRM1, ITPR3 | GPR3 1178/4885LMNA 1648/4885MEN1 2329/4885 |
| US-20080004262-A1 | Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents | CBR1, CBR3, SCN8A | GPR3 759/4885LMNA 2770/4885MEN1 4065/4885 |
| US-20160368883-A1 | ISOXAZOLINE DERIVATIVES AS INSECTICIDES | ACHE, CHRM1, ITPR3 | GPR3 1178/4885LMNA 1648/4885MEN1 2329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.