Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 8/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 2/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.52 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11591794 | 0.82 | HTT (0.59) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL30374699 | 0.80 | MKNK1 (0.58) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL29380490 | 0.80 | HTT (0.62) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL1095418 | 0.80 | CYP1A2 (0.60) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL21914 | 0.80 | HTT (0.62) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL160074 | 0.80 | CYP3A4 (0.62) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL29420373 | 0.80 | CYP3A4 (0.62) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL17901710 | 0.80 | HTT (0.57) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL10918760 | 0.78 | HTT (0.60) | HTTCYP3A4LMNACYP1A2PAK1 | |
| SCHEMBL6243538 | 0.78 | HTT (0.60) | HTTCYP3A4LMNACYP1A2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478928-A | Useful as antiviral agents in the treatment and prevention of AIDS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-12-26 | — | — | US | claimed |
| WO-1995011685-A1 | 2',3'-DIDEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-05-04 | — | — | WO | claimed |
| US-5478928-A | Useful as antiviral agents in the treatment and prevention of AIDS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-12-26 | — | — | US | disclosed |
| WO-1995011685-A1 | 2',3'-DIDEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-05-04 | — | — | WO | disclosed |
| EP-0525106-A4 | 2',3'-DIDEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AGENTS | — | 1993-04-21 | — | — | EP | disclosed |
| EP-0525106-A1 | 2',3'-DIDEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5128458-A | 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents | SOUTHERN RESEARCH INSTITUTE (US) | 1992-07-07 | — | — | US | disclosed |
| WO-1991016333-A1 | 2',3'-DIDEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AGENTS | SOUTHERN RESEARCH INSTITUTE (US) | 1991-10-31 | — | — | WO | disclosed |