Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | HINT1 | P49773 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9116775 | 0.90 | KDM4E (0.42) | KDM4ETAS1R3TAS1R1TAAR1ADORA2A | |
| SCHEMBL441420 | 0.88 | TAS1R3 (0.44) | KDM4ETAS1R3TAS1R1TAAR1ADORA2A | |
| SCHEMBL2113123 | 0.86 | KDM4E (0.50) | KDM4ETAS1R3TAS1R1TAAR1ADORA3 | |
| SCHEMBL2115345 | 0.81 | TAS1R3 (0.52) | TAS1R3TAS1R1TAAR1ADORA2AADORA3 | |
| SCHEMBL441421 | 0.78 | TYMP (0.48) | KDM4ETAS1R3TAS1R1TAAR1ADORA2A | |
| SCHEMBL9155236 | 0.77 | TAS1R3 (0.36) | KDM4ETAS1R3TAS1R1TAAR1 | |
| SCHEMBL2113125 | 0.77 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1TAAR1PDE9A | |
| SCHEMBL7534659 | 0.77 | KDM4E (0.49) | KDM4ETAS1R3TAS1R1TAAR1PDE9A | |
| SCHEMBL5963306 | 0.76 | TYMP (0.44) | KDM4ETAS1R3TAS1R1TAAR1ADORA2A | |
| SCHEMBL9294603 | 0.76 | TYMP (0.44) | KDM4ETAS1R3TAS1R1TAAR1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651759-A4 | NOVEL 2'-O-ALKYL NUCLEOSIDES AND PHOSPHORAMIDITES PROCESSES FOR THE PREPARATION AND USES THEREOF. | ISIS PHARMACEUTICALS INC (US) | 1995-10-25 | — | — | EP | disclosed |
| EP-0651759-A1 | NOVEL 2'-O-ALKYL NUCLEOSIDES AND PHOSPHORAMIDITES PROCESSES FOR THE PREPARATION AND USES THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002501-A1 | NOVEL 2'-O-ALKYL NUCLEOSIDES AND PHOSPHORAMIDITES PROCESSES FOR THE PREPARATION AND USES THEREOF | ISIS PHARMACEUTICALS, INC. (US) | 1994-02-03 | — | — | WO | disclosed |