Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HINT1 | P49773 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534659 | 0.90 | KDM4E (0.49) | KDM4EPOLA1TYMPTAS1R3TAS1R1 | |
| SCHEMBL2113125 | 0.90 | KDM4E (0.49) | KDM4EPOLA1TYMPTAS1R3TAS1R1 | |
| SCHEMBL441420 | 0.88 | TAS1R3 (0.44) | KDM4ETYMPTAS1R3TAS1R1TAAR1 | |
| SCHEMBL8916727 | 0.87 | POLB (0.45) | TYMPTAS1R3TAS1R1TAAR1POLB | |
| SCHEMBL9116771 | 0.86 | KDM4E (0.42) | KDM4ETYMPTAS1R3TAS1R1TAAR1 | |
| SCHEMBL10491022 | 0.82 | TYMP (0.54) | KDM4EPOLA1TYMPTAS1R3TAS1R1 | |
| SCHEMBL2115345 | 0.82 | TAS1R3 (0.52) | TYMPTAS1R3TAS1R1TAAR1ADORA3 | |
| SCHEMBL14556177 | 0.81 | TYMP (0.38) | TYMP | |
| SCHEMBL9790905 | 0.81 | ALDH1A1 (0.44) | KDM4EPOLA1TYMPTAS1R3TAS1R1 | |
| SCHEMBL2113458 | 0.80 | POLB (0.38) | KDM4EPOLBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158770-B2 | Content dependent inhibitors of cytidine deaminases and uses thereof | UNIVERSITY OF ROCHESTER (US) | 2012-04-17 | — | — | US | disclosed |
| US-7629447-B2 | Dideoxynucleoside derivatives | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2009-12-08 | — | — | US | disclosed |
| US-20090099105-A1 | Content dependent inhibitors of cytidine deaminases and uses thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-04-16 | — | — | US | disclosed |
| US-20080064868-A1 | Novel Dideoxynucleoside Derivatives | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2008-03-13 | — | — | US | disclosed |
| US-7135564-B1 | Reusable solid support for oligonucleotide synthesis | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 2006-11-14 | — | — | US | disclosed |
| EP-0877751-B1 | LINKER ARM FOR SOLID SUPPORT OLIGONUCLEOTIDE SYNTHESIS AND PROCESS FOR PRODUCTION THEREOF | UNIV TECHNOLOGIES INT (CA) | 2003-10-15 | — | — | EP | disclosed |
| US-20030129593-A1 | Process for producing multiple oligonucleotides on a solid support | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. | 2003-07-10 | — | — | US | disclosed |
| EP-1319012-A1 | PROCESS FOR PRODUCING MULTIPLE OLIGONUCLEOTIDES ON A SOLID SUPPORT | University Technologies International Inc. (CA) | 2003-06-18 | — | — | EP | disclosed |
| EP-0876390-B1 | REUSABLE SOLID SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS, PROCESS FOR PRODUCTION THEREOF AND PROCESS FOR USE THEREOF | UNIV TECHNOLOGIES INT (CA) | 2002-06-12 | — | — | EP | disclosed |
| WO-2002020541-A2 | PROCESS FOR PRODUCING MULTIPLE OLIGONUCLEOTIDES ON A SOLID SUPPORT | UNIVERSITY TECHNOLOGIES INTERNATIONAL INC. (CA) | 2002-03-14 | — | — | WO | disclosed |
| US-5552535-A | Multiple oligonucleotide containing oligomers and the cleanable linkers used in their preparation | ZENECA LIMITED (GB) | 1996-09-03 | — | — | US | disclosed |
| US-5393877-A | Forming first oligonucleotide on first cleavable link attached to solid support, attaching a cleavable linker moiety, forming second oligonucleotide on the cleavable linker moiety, cleaving to give plurality of oligonucleotides | ZENECA LIMITED (GB) | 1995-02-28 | — | — | US | disclosed |
| EP-0633890-A1 | SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS | ZENECA LIMITED (GB) | 1995-01-18 | — | — | EP | disclosed |
| WO-1993020091-A1 | SUPPORT FOR OLIGONUCLEOTIDE SYNTHESIS | ZENECA LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |
| WO-1993020092-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | ZENECA LIMITED (GB) | 1993-10-14 | — | — | WO | disclosed |
| EP-0552185-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | ZENECA LIMITED (GB) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006103-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-04-16 | — | — | WO | disclosed |
| EP-0202758-B1 | HYBRIDIZATION METHOD AND PROBES THEREFOR | Zeneca Limited (GB) | 1991-09-25 | — | — | EP | disclosed |
| EP-0305201-A2 | Protected biotin derivatives | ZENECA LIMITED (GB) | 1989-03-01 | — | — | EP | disclosed |
| EP-0202758-A1 | Hybridization method and probes therefor | ZENECA LIMITED (GB) | 1986-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030129593-A1 | Process for producing multiple oligonucleotides on a solid support | RNGTT, IGF2BP1, IGF2BP2 | KDM4E 2730/4885POLA1 247/4885TYMP 116/4885 |
| US-20090099105-A1 | Content dependent inhibitors of cytidine deaminases and uses thereof | DCTD, CDA, ADA | KDM4E 1115/4885POLA1 319/4885TYMP 22/4885 |
| US-20080064868-A1 | Novel Dideoxynucleoside Derivatives | DNA2, DDX20, DNASE1 | KDM4E 2700/4885POLA1 98/4885TYMP 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.