SCHEMBL9116949

SCHEMBL9116949

O=C(/C=C/c1ccccc1)OC(=O)CC(=O)OC(=O)/C=C/c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.57
AKR1B10 O60218 2/20 0.54
AKR1B1 P15121 2/20 0.54
MAPT P10636 3/20 0.53
ALDH1A1 P00352 3/20 0.53
HDAC3 O15379 2/20 0.53
HDAC4 P56524 2/20 0.53
HDAC1 Q13547 2/20 0.53
HDAC2 Q92769 2/20 0.53
HDAC8 Q9BY41 2/20 0.53
HDAC6 Q9UBN7 2/20 0.53
PLIN1 O60240 2/20 0.53
RECQL P46063 2/20 0.53
PLIN5 Q00G26 2/20 0.53
ABHD5 Q8WTS1 2/20 0.53
TNKS O95271 1/20 0.53
HCAR2 Q8TDS4 1/20 0.53
HDAC7 Q8WUI4 1/20 0.53
HDAC10 Q969S8 1/20 0.53
HDAC11 Q96DB2 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10867134 0.93 LMNA (0.51) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL28160312 0.90 GLA (0.53) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL11317021 0.89 LMNA (0.57) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL27732204 0.87 LMNA (0.56) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL27732203 0.87 LMNA (0.56) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL775716 0.86 MAPT (0.64) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL9247555 0.86 MAPT (0.64) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL21803794 0.86 MAPT (0.64) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL29257442 0.86 LMNA (0.54) LMNAAKR1B10AKR1B1MAPTALDH1A1
SCHEMBL9551621 0.86 LMNA (0.54) LMNAAKR1B10AKR1B1MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4613499-A Substituted cinnamal dialkyl malonates in sunscreening, skin care compositions VAN DYK & COMPANY INC. (US) 1986-09-23 US claimed
EP-0165710-A1 Benzene sulfonate quaternary ammonium salts of organic sunscreen carboxylic acids VAN DYK & COMPANY, INC. (US) 1985-12-27 EP claimed
US-5424164-A Image forming method FUJI PHOTO FILM CO., LTD (JP) 1995-06-13 US disclosed
US-4680144-A HAIR CONDITIONERS MALLINCKRODT, INC. (US) 1987-07-14 US disclosed
US-4613499-A Substituted cinnamal dialkyl malonates in sunscreening, skin care compositions VAN DYK & COMPANY INC. (US) 1986-09-23 US disclosed
EP-0171875-A1 Liquid cinnamal dialkyl malonates as sole organic sunscreens VAN DYK & COMPANY, INC. (US) 1986-02-19 EP disclosed
EP-0165710-A1 Benzene sulfonate quaternary ammonium salts of organic sunscreen carboxylic acids VAN DYK & COMPANY, INC. (US) 1985-12-27 EP disclosed
US-4515774-A NON-POLAR OIL CARRIER VAN DYK & COMPANY INC. (US) 1985-05-07 US disclosed