Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115871 | 0.90 | PTGS2 (0.49) | PTGS2PTGS1EPAS1MAOAMAOB | |
| SCHEMBL9119080 | 0.90 | PTGS2 (0.52) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117966 | 0.90 | PTGS2 (0.49) | PTGS2PTGS1EPAS1NPC1ALOX15 | |
| SCHEMBL9117182 | 0.90 | PTGS2 (0.52) | PTGS2PTGS1EPAS1NPC1ALOX15 | |
| SCHEMBL9118736 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1EPAS1NPC1ALOX15 | |
| SCHEMBL9117131 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL9117792 | 0.85 | PTGS2 (0.77) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9115547 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1MAOAMAOBCA12 | |
| SCHEMBL9119151 | 0.83 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL9118066 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1APEX1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |