Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.52 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117966 | 0.90 | PTGS2 (0.49) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117650 | 0.90 | PTGS2 (0.54) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117649 | 0.88 | PTGS2 (0.52) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117182 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9118503 | 0.86 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL9118357 | 0.86 | PTGS2 (0.62) | PTGS2PTGS1SOS1 | |
| SCHEMBL9115871 | 0.85 | PTGS2 (0.49) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117096 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1EPAS1HTTSMN1; SMN2 | |
| SCHEMBL9118736 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1EPAS1HTT | |
| SCHEMBL9119247 | 0.84 | PTGS2 (0.51) | PTGS2PTGS1EPAS1USP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |