Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HSD17B13 | Q7Z5P4 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19359494 | 0.81 | TSHR (0.50) | CYP3A4HSD17B13SMN1; SMN2KDM4EADORA2B | |
| SCHEMBL27383559 | 0.81 | HSD17B13 (0.51) | CYP3A4HSD17B13TP53 | |
| SCHEMBL19359478 | 0.80 | FAAH (0.49) | KDM4EGSK3AGSK3BLMNA | |
| SCHEMBL5800712 | 0.80 | HPGD (0.49) | CYP3A4SMN1; SMN2HTTKDM4ETP53 | |
| SCHEMBL4494422 | 0.79 | MAPK14 (0.46) | CYP3A4SMN1; SMN2HTTKDM4ETP53 | |
| SCHEMBL27478800 | 0.78 | F2 (0.54) | SMN1; SMN2HTTKDM4ETP53CYP2D6 | |
| SCHEMBL7521742 | 0.78 | HTT (0.45) | SMN1; SMN2HTTKDM4ETP53CYP2D6 | |
| SCHEMBL27422651 | 0.78 | MAPK14 (0.47) | SMN1; SMN2HTTKDM4ETP53CYP2D6 | |
| SCHEMBL8301883 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2HTTKDM4ETP53CYP2D6 | |
| SCHEMBL13947776 | 0.77 | HSD17B13 (0.43) | HSD17B13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5418231-A | Pyrimido-benzothiazines | PFIZER INC. (US) | 1995-05-23 | — | — | US | disclosed |
| EP-0566592-B1 | Pyrimido-benzothiazines with lipoxygenase inhibitory action | PFIZER (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0566592-A1 | NOVEL PYRIMIDO-BENZOTHIAZINES. | PFIZER (US) | 1993-10-27 | — | — | EP | disclosed |
| WO-1992012161-A1 | NOVEL PYRIMIDO-BENZOTHIAZINES | PFIZER INC. (US) | 1992-07-23 | — | — | WO | disclosed |