Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121185 | 0.89 | MAPT (0.41) | LTB4RKMT2ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL9121570 | 0.86 | LTB4R (0.47) | LTB4RKMT2ASMN1; SMN2MAOBMAPT | |
| SCHEMBL9122890 | 0.85 | KMT2A (0.47) | LTB4RKMT2ASMN1; SMN2MAOBMAPT | |
| SCHEMBL9121437 | 0.85 | LTB4R (0.44) | LTB4RMAPTLTB4R2 | |
| SCHEMBL9119818 | 0.84 | PDE3B (0.43) | LTB4RKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL9121426 | 0.82 | PPARD (0.49) | LTB4RKMT2AALDH1A1MEN1LTB4R2 | |
| SCHEMBL8800245 | 0.80 | LTB4R (0.42) | LTB4RKMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8799495 | 0.78 | MEN1 (0.48) | LTB4RKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL17329439 | 0.76 | KMT2A (0.55) | KMT2AMAOBALDH1A1MEN1 | |
| SCHEMBL9121288 | 0.76 | TDP1 (0.46) | LTB4RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |