Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799495 | 0.89 | MEN1 (0.48) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL8800390 | 0.88 | LTB4R (0.41) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL9117669 | 0.87 | BRD4 (0.45) | PDE3BPDE3AP2RY12MEN1KMT2A | |
| SCHEMBL8799721 | 0.87 | MEN1 (0.43) | PDE3BPDE3AP2RY12MTNR1BMTNR1A | |
| SCHEMBL9121185 | 0.86 | MAPT (0.41) | PPARGPPARAPPARDMAPTMTNR1B | |
| SCHEMBL9121261 | 0.86 | PDE3B (0.46) | PDE3BPDE3AP2RY12PPARGPPARA | |
| SCHEMBL9118524 | 0.84 | LTB4R (0.43) | MAPTLTB4RMEN1ALDH1A1KMT2A | |
| SCHEMBL9121437 | 0.83 | LTB4R (0.44) | PPARGPPARAPPARDMAPTLTB4R | |
| SCHEMBL9121426 | 0.82 | PPARD (0.49) | PPARGPPARDLTB4RMEN1ALDH1A1 | |
| SCHEMBL8800245 | 0.82 | LTB4R (0.42) | PPARGPPARAMAPTLTB4RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |