Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27871540 | 0.93 | CTSC (0.64) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL10879992 | 0.92 | CTSC (0.60) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL10879995 | 0.92 | CTSC (0.60) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL11642380 | 0.91 | CTSC (0.55) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL11599237 | 0.89 | CTSC (0.66) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL10750299 | 0.89 | CTSC (0.54) | CTSCACEECE1 | |
| SCHEMBL2195208 | 0.88 | CTSC (0.59) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL8892785 | 0.88 | CTSC (0.59) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL6906379 | 0.87 | CTSC (0.62) | CTSCKDM4EMAPTMEN1LMNA | |
| SCHEMBL2192888 | 0.87 | KDM4E (0.60) | CTSCKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995026744-A1 | TUMOR NECROSIS FACTOR INHIBITORS | CENTOCOR, INC. (US) | 1995-10-12 | — | — | WO | disclosed |
| US-4058513-A | LUTEINIZING HORMONE RELEASING | PARKE, DAVIS & COMPANY (US) | 1977-11-15 | — | — | US | disclosed |