Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4987178 | 0.82 | NOS3 (0.59) | NOS3NOS1NOS2NOX1AR | |
| SCHEMBL9119429 | 0.81 | APP (0.44) | MAOBKMT2A | |
| SCHEMBL8202043 | 0.79 | NOX1 (0.53) | NOX1ALDH1A1ARLMNACYP1A2 | |
| SCHEMBL4984504 | 0.79 | AR (0.45) | NOS3NOS1NOS2NOX1ALDH1A1 | |
| SCHEMBL9118646 | 0.77 | NOX1 (0.62) | NOX1ALDH1A1ARLMNACYP1A2 | |
| SCHEMBL4985844 | 0.76 | BCHE (0.44) | NOS3NOS1NOS2ALDH1A1AR | |
| SCHEMBL4982900 | 0.75 | NOS3 (0.51) | NOS3NOS1NOS2NOX1SCN2A | |
| SCHEMBL4980025 | 0.75 | PTGS1 (0.56) | NOX1ALDH1A1ARLMNACYP1A2 | |
| SCHEMBL4983731 | 0.73 | NOS3 (0.52) | NOS3NOS1NOS2ALOX5 | |
| SCHEMBL4982640 | 0.72 | NOX1 (0.46) | NOS3NOS1NOS2NOX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995020950-A1 | THERAPEUTIC GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1995-08-10 | — | — | WO | disclosed |