Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118171 | 0.91 | PTGS2 (0.57) | PTGS2PTGS1POLBTSHRKMT2A | |
| SCHEMBL9117634 | 0.91 | PTGS2 (0.57) | PTGS2PTGS1TSHRMAPK1MAPT | |
| SCHEMBL9117521 | 0.91 | PTGS2 (0.57) | PTGS2PTGS1KMT2A | |
| SCHEMBL9117087 | 0.90 | PTGS2 (0.75) | PTGS2PTGS1 | |
| SCHEMBL9117671 | 0.89 | PTGS2 (0.52) | PTGS2PTGS1POLBKMT2AMAPT | |
| SCHEMBL9118113 | 0.85 | PTGS2 (0.79) | PTGS2PTGS1POLBTSHRMAPK1 | |
| SCHEMBL9116418 | 0.84 | PTGS2 (0.60) | PTGS2PTGS1POLBTSHRMAPK1 | |
| SCHEMBL9116116 | 0.84 | PTGS2 (0.62) | PTGS2PTGS1MAPK1KMT2AMAPT | |
| SCHEMBL9116863 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1POLBTSHRMAPK1 | |
| SCHEMBL9117086 | 0.82 | PTGS2 (0.46) | PTGS2PTGS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |