Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118751 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1TSHRMAPK1MAPT | |
| SCHEMBL9118171 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1TSHRLMNAGAA | |
| SCHEMBL9117521 | 0.88 | PTGS2 (0.57) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL9117087 | 0.87 | PTGS2 (0.75) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL9118021 | 0.87 | PTGS2 (0.50) | PTGS2PTGS1TDP1HTTLMNA | |
| SCHEMBL9116789 | 0.85 | PTGS2 (0.76) | PTGS2PTGS1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9118082 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1TSHRSMN1; SMN2LMNA | |
| SCHEMBL9117671 | 0.85 | PTGS2 (0.52) | PTGS2PTGS1GAAALDH1A1MAPT | |
| SCHEMBL9118660 | 0.84 | PTGS1 (0.48) | PTGS2PTGS1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9119158 | 0.84 | PTGS2 (0.60) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |