Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 12/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 12/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23882933 | 0.78 | MAPT (0.43) | LTB4RLTB4R2DRD2 | |
| SCHEMBL9122715 | 0.73 | LTB4R (0.75) | LTB4RLTB4R2 | |
| SCHEMBL9120331 | 0.72 | LTB4R (0.56) | LTB4RLTB4R2 | |
| SCHEMBL30251527 | 0.72 | LTB4R (0.56) | LTB4RLTB4R2 | |
| SCHEMBL23905925 | 0.72 | LTB4R (0.59) | LTB4RLTB4R2 | |
| SCHEMBL30251093 | 0.71 | LTB4R (0.58) | LTB4RLTB4R2 | |
| SCHEMBL23882677 | 0.71 | LTB4R (0.58) | LTB4RLTB4R2 | |
| SCHEMBL9124055 | 0.70 | LTB4R (0.78) | LTB4RLTB4R2 | |
| SCHEMBL9121352 | 0.68 | LTB4R (0.89) | LTB4RLTB4R2 | |
| SCHEMBL551972 | 0.68 | MAOB (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |