Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119779 | 0.87 | PKM (0.48) | L3MBTL1PKMALDH1A1MAPTHTT | |
| SCHEMBL6924337 | 0.84 | SLC6A4 (0.59) | L3MBTL1PKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14564455 | 0.82 | TRPV1 (0.50) | L3MBTL1PKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7649536 | 0.82 | TDP1 (0.59) | L3MBTL1PKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16547427 | 0.81 | SLC6A3 (0.57) | L3MBTL1PKMALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5412400 | 0.81 | SLC6A4 (0.59) | L3MBTL1PKMALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL812065 | 0.80 | KDM4E (0.59) | L3MBTL1PKMALDH1A1HTTTDP1 | |
| SCHEMBL4206899 | 0.78 | TRPV1 (0.54) | TDP1METAP2 | |
| SCHEMBL28797930 | 0.77 | TRPV1 (0.58) | ALDH1A1MAPTTDP1METAP2KDM4E | |
| SCHEMBL9118970 | 0.77 | TDP1 (0.47) | L3MBTL1PKMALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451583-A | Angiotensin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5283242-A | Hypotensive agents, cardiotonic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-02-01 | — | — | US | disclosed |