Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11606936 | 0.91 | LMNA (0.41) | LMNACYP3A4PSIP1CYP2D6MAPK1 | |
| SCHEMBL28010748 | 0.87 | TSHR (0.40) | KMT2APSIP1TSHRSMN1; SMN2HSD11B1 | |
| Choline SCHEMBL506429 | 0.85 | CYP3A4 (0.46) | LMNACYP3A4MEN1KMT2ASLC5A7 | |
| SCHEMBL11609994 | 0.84 | CHRM2 (0.41) | LMNACYP3A4PSIP1CYP2D6MAPK1 | |
| Choline SCHEMBL28623707 | 0.84 | CYP3A4 (0.46) | LMNACYP3A4MEN1KMT2ASLC5A7 | |
| Choline SCHEMBL11607099 | 0.83 | TSHR (0.61) | LMNACYP3A4MEN1KMT2ASLC5A7 | |
| Choline SCHEMBL28992902 | 0.82 | CYP3A4 (0.45) | LMNACYP3A4MEN1KMT2ASLC5A7 | |
| Choline SCHEMBL5810954 | 0.82 | LMNA (0.40) | LMNACYP3A4MEN1KMT2ASLC5A7 | |
| Ethylene Glycol SCHEMBL28496865 | 0.82 | SMN1; SMN2 (0.46) | LMNAKMT2APSIP1MAPK1TSHR | |
| Tetramethylammonium Ion SCHEMBL240527 | 0.82 | HTR6 (0.48) | LMNACYP3A4MEN1KMT2APSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119896763-A | Pasty biological tissue adhesive capable of being coated and preparation method and application thereof | 哈尔滨工业大学 | 2025-04-29 | — | — | CN | claimed |
| CN-117069901-A | Lignin-based phenolic resin and preparation method thereof | 江苏理文造纸有限公司 | 2023-11-17 | — | — | CN | claimed |
| WO-1995029923-A1 | PROCESS FOR THE PREPARATION OF MONO- AND BIS(PHOSPHOCHOLINE) DERIVATIVES WHICH HAVE ANTIFUNGAL ACTIVITY | SHAMAN PHARMACEUTICALS, INC. (US) | 1995-11-09 | — | — | WO | claimed |
| EP-4689232-A2 | SUSTAINABLE PREPARATION OF HEXAMETHYLENE DIISOCYANATE FOR THE PRODUCTION OF POLYURETHANE | Covestro Deutschland AG (DE) | 2026-02-11 | — | — | EP | disclosed |
| CN-119896763-A | Pasty biological tissue adhesive capable of being coated and preparation method and application thereof | 哈尔滨工业大学 | 2025-04-29 | — | — | CN | disclosed |
| WO-2024208940-A2 | SUSTAINABLE PREPARATION OF HEXAMETHYLENE DIISOCYANATE FOR THE PRODUCTION OF POLYURETHANE | COVESTRO DEUTSCHLAND AG (DE) | 2024-10-10 | — | — | WO | disclosed |
| EP-4442859-A1 | SUSTAINABLE PRODUCTION OF HEXAMETHYLENE DIISOCYANATE FOR THE PRODUCTION OF POLYURETHANE | Covestro Deutschland AG (DE) | 2024-10-09 | — | — | EP | disclosed |
| CN-117069901-A | Lignin-based phenolic resin and preparation method thereof | 江苏理文造纸有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-101502728-A | Defoaming of ionic liquids | EVONIK GOLDSCHMIDT GMBH (DE) | 2009-08-12 | — | — | CN | disclosed |
| US-4105858-A | Quaternary salts of methacrylic or acrylic esters and cationic quaternary polyelectrolytes and ion exchange resins thereof | CESKOSLOVENSKA AKADEMIE VED (CS) | 1978-08-08 | — | — | US | disclosed |
| US-4077963-A | Quaternary salts of methacrylic or acrylic esters | CESKOSLOVENSAK AKADEMIE VED (CS) | 1978-03-07 | — | — | US | disclosed |
| US-4011204-A | QUATERNARY SALTS OF METHACRYLIC OR ACRYLIC ESTERS AND CATIONIC QUATERNAY POLYELECTROLYTES AND ION EXCHANGE RESINS THEREOF | CESKOSLOVENSKA AKADEMIE VED (CS) | 1977-03-08 | — | — | US | disclosed |