Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3520851 | 0.82 | PDE3B (0.47) | TDP1CHEK1LMNAHSD17B10PDE3B | |
| SCHEMBL2896019 | 0.82 | HSD17B10 (0.65) | TDP1POLBLMNAHSD17B10ALDH1A1 | |
| SCHEMBL9667448 | 0.79 | HSD17B10 (0.47) | TDP1CHEK1POLBLMNAHSD17B10 | |
| SCHEMBL22460138 | 0.79 | BCHE (0.64) | MAPK9MAPK10TDP1CHEK1POLB | |
| SCHEMBL24484066 | 0.79 | HSD17B10 (0.47) | TDP1POLBLMNAHSD17B10ALDH1A1 | |
| SCHEMBL23565310 | 0.79 | ALDH1A1 (0.50) | TDP1POLBLMNAHSD17B10ALDH1A1 | |
| SCHEMBL3921034 | 0.79 | KMT2A (0.51) | TDP1POLBLMNAHSD17B10ALDH1A1 | |
| SCHEMBL1544475 | 0.79 | HSD17B10 (0.71) | TDP1POLBBCHELMNAHSD17B10 | |
| SCHEMBL9667403 | 0.78 | PDE3B (0.43) | MAPK9MAPK10TDP1CHEK1HSD17B10 | |
| SCHEMBL10555376 | 0.76 | ALDH1A1 (0.53) | TDP1POLBLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436252-A | Antiischemic agents, stroke, Alzheimer's or Parkinson's diseases | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0273310-B1 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use as anticonvulsants | MERRELL DOW PHARMA (US) | 1995-06-21 | — | — | EP | disclosed |
| EP-0273309-B1 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders | MERRELL DOW PHARMA (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0273309-A2 | 5-Aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-07-06 | — | — | EP | disclosed |