Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670178 | 0.86 | CYP19A1 (0.52) | MMP2MMP13MMP14CHEK1CLK2 | |
| SCHEMBL9668918 | 0.84 | KDM4E (0.36) | CHEK1HSD17B10KDM4EMAPTHPGD | |
| SCHEMBL9669151 | 0.81 | KDM4E (0.43) | MAPK9MAPK10HSD17B10KDM4EMAPT | |
| SCHEMBL9119099 | 0.78 | MAPK9 (0.50) | PDE3BPDE3AMAPK9MAPK10CHEK1 | |
| SCHEMBL31317792 | 0.76 | CLK1 (0.54) | PDE3BPDE3AMMP2MMP13MMP14 | |
| SCHEMBL21812414 | 0.76 | CLK1 (0.54) | PDE3BPDE3AMMP2MMP13MMP14 | |
| SCHEMBL9669274 | 0.76 | CHRNA7 (0.44) | HSD17B10KDM4EMAPTHPGDTSHR | |
| SCHEMBL10556977 | 0.76 | CLK2 (0.41) | PDE3BPDE3AMAPK9MAPK10CHEK1 | |
| SCHEMBL16382915 | 0.73 | NPC1 (0.56) | HSD17B10KDM4EMAPTHPGDGFER | |
| SCHEMBL10553367 | 0.72 | PDE3B (0.42) | PDE3BPDE3AMMP2MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |