Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119228 | 0.76 | MEN1 (0.48) | MEN1KMT2ACNR1CNR2ALDH1A1 | |
| SCHEMBL9120012 | 0.76 | FOLH1 (0.47) | MAPK1L3MBTL1FOLH1TSHRTDP1 | |
| SCHEMBL8003850 | 0.75 | MEN1 (0.48) | MEN1KMT2AL3MBTL1TSHRTDP1 | |
| SCHEMBL22325517 | 0.74 | MEN1 (0.48) | MEN1KMT2AL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL11537124 | 0.74 | MEN1 (0.50) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL1263510 | 0.74 | MEN1 (0.50) | MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL6722595 | 0.74 | MEN1 (0.54) | MEN1KMT2APPARGPPARAACACB | |
| SCHEMBL10682289 | 0.74 | MEN1 (0.49) | MEN1KMT2ACNR1CNR2PPARG | |
| SCHEMBL10677816 | 0.74 | MEN1 (0.49) | MEN1KMT2ACNR1CNR2PPARG | |
| SCHEMBL10678596 | 0.74 | MEN1 (0.49) | MEN1KMT2ACNR1CNR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |