Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9122597 | 0.96 | LTB4R (0.54) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL9119104 | 0.95 | PPARD (0.52) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL31155910 | 0.94 | PPARD (0.54) | PPARDPPARGLTB4RLTB4R2CNR2 | |
| SCHEMBL31155865 | 0.93 | PPARD (0.53) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL25168679 | 0.89 | PPARG (0.62) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL3266929 | 0.89 | PPARD (0.54) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL31155854 | 0.89 | PPARD (0.54) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL28915626 | 0.86 | PPARD (0.64) | PPARDPPARGLTB4RLTB4R2PPARA | |
| SCHEMBL8286477 | 0.86 | PPARD (0.54) | PPARDPPARGLTB4RLTB4R2CNR2 | |
| SCHEMBL31155848 | 0.85 | PPARD (0.52) | PPARDPPARGLTB4RLTB4R2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |