Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.61 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 10/20 | 0.53 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | REN | P00797 | 5/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | C1S | P09871 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118827 | 0.92 | LTB4R (0.73) | LTB4RLTB4R2PRSS1RENHTR1A | |
| Hydrochloric Acid SCHEMBL8994911 | 0.91 | LTB4R (0.72) | LTB4RLTB4R2PRSS1RENHTR1A | |
| SCHEMBL9119317 | 0.84 | LTB4R (0.48) | LTB4RLTB4R2NR1H3RENHTR1A | |
| SCHEMBL8995067 | 0.83 | LTB4R (0.57) | LTB4RLTB4R2RENHTR1AADRA1D | |
| SCHEMBL9118833 | 0.80 | LTB4R (0.54) | LTB4RLTB4R2RENHTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL8994925 | 0.80 | LTB4R (0.53) | LTB4RLTB4R2RENHTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL8994844 | 0.79 | LTB4R (0.67) | LTB4RLTB4R2PRSS1F2 | |
| Moxilubant SCHEMBL6439215 | 0.77 | LTB4R (1.00) | LTB4RLTB4R2PRSS1F10HTR2A | |
| Moxilubant SCHEMBL29388138 | 0.77 | LTB4R (1.00) | LTB4RLTB4R2PRSS1F10HTR2A | |
| Moxilubant SCHEMBL8994884 | 0.76 | LTB4R (0.98) | LTB4RLTB4R2PRSS1F10HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | claimed |