Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.54 |
| ▸ | REN | P00797 | 11/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118827 | 0.89 | LTB4R (0.73) | LTB4RLTB4R2RENHTR1AADRA1D | |
| SCHEMBL8994986 | 0.89 | HTT (0.53) | LTB4RLTB4R2PLA2G4BMAPTPOLB | |
| Hydrochloric Acid SCHEMBL8994911 | 0.88 | LTB4R (0.72) | LTB4RLTB4R2RENHTR1AADRA1D | |
| SCHEMBL8994887 | 0.85 | LTB4R (0.76) | LTB4RLTB4R2PLA2G4BMAPTPOLB | |
| SCHEMBL9119310 | 0.83 | LTB4R (0.61) | LTB4RLTB4R2RENHTR1AADRA1D | |
| SCHEMBL8994912 | 0.82 | LTB4R (0.59) | LTB4RLTB4R2PLA2G4BMAPTPOLB | |
| SCHEMBL9118833 | 0.82 | LTB4R (0.54) | LTB4RLTB4R2RENHTR1AADRA1D | |
| Hydrochloric Acid SCHEMBL8994925 | 0.81 | LTB4R (0.53) | LTB4RLTB4R2RENHTR1AADRA1D | |
| SCHEMBL8994951 | 0.80 | DRD2 (0.56) | PLA2G4BMAPT | |
| SCHEMBL8995031 | 0.80 | LTB4R (0.56) | LTB4RLTB4R2PLA2G4BMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |