Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18611964 | 0.89 | MAOB (0.52) | MAOBMAOASLC2A1LMNAALDH1A1 | |
| SCHEMBL18591911 | 0.87 | MAOB (0.52) | MAOBMAOASLC2A1LMNAALDH1A1 | |
| SCHEMBL6986259 | 0.82 | HSD17B10 (0.53) | MAOBSLC2A1LMNAALDH1A1MAPK1 | |
| SCHEMBL7467756 | 0.82 | RARB (0.49) | MAOBMAOALMNAALDH1A1KDM4E | |
| SCHEMBL8118515 | 0.80 | MAOB (0.55) | MAOBMAOAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL648621 | 0.80 | MAOB (0.70) | MAOBALDH1A1KDM4E | |
| SCHEMBL13740830 | 0.79 | CA12 (0.57) | MAOBMAOASLC2A1LMNAALDH1A1 | |
| SCHEMBL6867907 | 0.79 | MAOB (0.54) | MAOBMAOAALDH1A1MAPK1KDM4E | |
| SCHEMBL10507360 | 0.79 | CA12 (0.54) | MAOBSLC2A1LMNAALDH1A1MAPK1 | |
| SCHEMBL3618447 | 0.79 | MAOB (0.62) | MAOBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |