Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28847207 | 0.87 | KDM4E (0.54) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL28953715 | 0.84 | ALDH1A1 (0.55) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL19328399 | 0.83 | ALDH1A1 (0.42) | KDM4EALDH1A1PKMSMN1; SMN2LMNA | |
| SCHEMBL3630965 | 0.82 | ALDH1A1 (0.43) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL4209039 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL5882305 | 0.79 | ERN1 (0.50) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL30304115 | 0.79 | KMT2A (0.56) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL14785176 | 0.79 | KMT2A (0.56) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL30902395 | 0.79 | ERN1 (0.50) | KDM4EALDH1A1PKMMAPTS1PR4 | |
| SCHEMBL1283086 | 0.78 | MAPT (0.58) | KDM4EALDH1A1MAPTS1PR4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |