Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 8/20 | 0.48 |
| ▸ | CNR1 | P21554 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569884 | 0.87 | CNR2 (0.54) | CNR2CNR1PPARGCYP4F2CYP4A11 | |
| SCHEMBL8799756 | 0.87 | PPARG (0.44) | CNR2CNR1PPARGCYP4F2CYP4A11 | |
| SCHEMBL9121586 | 0.85 | LTB4R (0.58) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL9121682 | 0.85 | LTB4R (0.58) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL9119987 | 0.85 | LTB4R (0.58) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL9119183 | 0.85 | LTB4R (0.58) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL9119413 | 0.85 | LTB4R (0.58) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL200784 | 0.84 | LTB4R (0.55) | CNR2CNR1CYP4F2CYP4A11LTB4R | |
| SCHEMBL6755950 | 0.83 | CNR1 (0.57) | CNR2CNR1PPARGLTB4RLTB4R2 | |
| SCHEMBL6757559 | 0.83 | PPARG (0.42) | CNR2CNR1PPARGLTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434186-A | Antiinflammatory agents | HOFFMANN-LA ROCHE INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5273999-A | A 4-keto-boroalkyleneoxychroman or 2,3-dihydrobenzofuran derivative | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0531823-A1 | Bicyclic carboxylic acid derivatives as anti-inflammatory agents | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-17 | — | — | EP | disclosed |