SCHEMBL9119459

SCHEMBL9119459

CCCN1CC[C@H]2c3cccc(OC(=O)N(C)C)c3CC[C@H]21

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 10/20 0.69
DRD2 P14416 5/20 0.62
DRD1 P21728 2/20 0.62
DRD4 P21917 2/20 0.62
DRD5 P21918 2/20 0.62
DRD3 P35462 2/20 0.62
ACHE P22303 4/20 0.60
CHRM2 P08172 1/20 0.60
CHRM1 P11229 1/20 0.60
CHRM3 P20309 1/20 0.60
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9441334 1.00 HTR1A (0.69) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9119739 0.89 ACHE (0.62) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9441236 0.89 ACHE (0.62) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9120145 0.89 ACHE (0.60) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9441382 0.89 ACHE (0.60) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9119775 0.88 ACHE (0.57) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9441067 0.88 ACHE (0.57) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9120701 0.88 ACHE (0.78) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9118592 0.88 ACHE (0.57) HTR1ADRD2DRD1DRD4DRD5
SCHEMBL9119786 0.88 ACHE (0.57) HTR1ADRD2DRD1DRD4DRD5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0548664-B1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives HOFFMANN LA ROCHE (CH) 1995-05-31 EP disclosed
US-5318966-A Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US disclosed
US-5318967-A Cognition activators for alzheimer's disease, learning enhancement HOFFMANN-LA ROCHE INC. (US) 1994-06-07 US disclosed
EP-0548664-A1 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP disclosed