Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15621991 | 0.85 | POLB (0.49) | ALDH1A1RAB9ASMN1; SMN2LMNACASP1 | |
| SCHEMBL749535 | 0.84 | ALOX5 (0.46) | ALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL29804911 | 0.84 | ALOX5 (0.46) | ALDH1A1SMN1; SMN2CYP2C9 | |
| SCHEMBL13347539 | 0.84 | MAPT (0.38) | ALDH1A1SMN1; SMN2TP53LMNACASP1 | |
| SCHEMBL22607785 | 0.80 | PARP1 (0.45) | ALDH1A1MAPT | |
| SCHEMBL9856069 | 0.77 | HDAC11 (0.34) | ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL30517094 | 0.77 | ALOX5 (0.51) | ALDH1A1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL984368 | 0.77 | ALOX5 (0.51) | ALDH1A1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL9225764 | 0.75 | AKR1C3 (0.47) | ALDH1A1RAB9ASMN1; SMN2AKR1C3GAA | |
| SCHEMBL27343882 | 0.75 | CTNNB1 (0.53) | ALDH1A1RAB9ASMN1; SMN2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461048-A | Tricyclic compounds having cholecystokinin antagonist activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5401737-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0360079-B1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-02-02 | — | — | EP | disclosed |
| US-5248679-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| CN-1022187-C | Method for preparation of tricyclic compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-09-22 | — | — | CN | disclosed |
| US-5155101-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-10-13 | — | — | US | disclosed |
| US-4981847-A | Tricyclic compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| CN-1040981-A | Tricyclic compound | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-04-04 | — | — | CN | disclosed |
| EP-0360079-A1 | Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-03-28 | — | — | EP | disclosed |