Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.67 |
| ▸ | HTR1A | P08908 | 8/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119644 | 1.00 | DRD2 (0.67) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL9121991 | 0.99 | DRD2 (0.69) | DRD2HTR1ADRD3 | |
| SCHEMBL9121998 | 0.99 | DRD2 (0.69) | DRD2HTR1ADRD3 | |
| SCHEMBL9117994 | 0.97 | DRD2 (0.66) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL9117991 | 0.97 | DRD2 (0.66) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL9118050 | 0.93 | DRD2 (0.70) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL9118057 | 0.93 | DRD2 (0.70) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9118521 | 0.92 | DRD2 (0.69) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9441210 | 0.92 | DRD2 (0.69) | DRD2HTR1ACHRM2CHRM1CHRM3 | |
| SCHEMBL9121623 | 0.92 | DRD2 (0.72) | DRD2HTR1ACHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | disclosed |
| US-5318966-A | Administering the enzyme inhibitor for treating alzheimer's disease, learning enhancement, brain disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| US-5318967-A | Cognition activators for alzheimer's disease, learning enhancement | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0548664-A1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |