Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9118970 | 0.88 | TDP1 (0.47) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL9301375 | 0.81 | SLC6A3 (0.57) | ALDH1A1KDM4ESLC6A3SLC6A4LMNA | |
| SCHEMBL16547421 | 0.80 | TDP1 (0.50) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL22717702 | 0.80 | SLC6A4 (0.50) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL22717355 | 0.80 | KMT2A (0.50) | TDP1PKML3MBTL1ALDH1A1KDM4E | |
| SCHEMBL29575477 | 0.80 | KMT2A (0.50) | TDP1PKML3MBTL1ALDH1A1KDM4E | |
| SCHEMBL29574044 | 0.80 | SLC6A4 (0.50) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL812065 | 0.80 | KDM4E (0.59) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL7362874 | 0.77 | KDM4E (0.50) | TDP1PKML3MBTL1MAP2K1ALDH1A1 | |
| SCHEMBL7367740 | 0.77 | KDM4E (0.47) | TDP1PKML3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451583-A | Angiotensin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1994011365-A1 | SUBSTITUTED BENZIMIDAZOLES AND QUINAZOLINES AS ANTIHYPERTENSIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| US-5283242-A | Hypotensive agents, cardiotonic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-02-01 | — | — | US | disclosed |