Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120355 | 0.71 | PTGS2 (0.40) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9738587 | 0.70 | PTGS1 (0.40) | PTGS2PTGS1ALOX5 | |
| SCHEMBL2694570 | 0.70 | PTGS2 (1.00) | PTGS2PTGS1ALOX5CA1CA2 | |
| SCHEMBL9182983 | 0.69 | PTGS2 (0.97) | PTGS2PTGS1ALOX5CA1CA2 | |
| SCHEMBL9122434 | 0.68 | PTGS2 (0.54) | PTGS2PTGS1KDM4EALDH1A1PPARG | |
| SCHEMBL9348996 | 0.64 | PTGS1 (0.76) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9122974 | 0.60 | PTGS1 (0.40) | PTGS2PTGS1 | |
| SCHEMBL9120689 | 0.60 | PTGS1 (0.35) | PTGS2PTGS1 | |
| SCHEMBL9738006 | 0.60 | PTGS1 (0.58) | PTGS2PTGS1ALOX5GAA | |
| SCHEMBL3618030 | 0.59 | PTGS1 (0.40) | PTGS2PTGS1ALDH1A1SMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356898-A | Antiinflammatory agents, antiallergens, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-10-18 | — | — | US | claimed |
| US-5432181-A | Substituted heteroaryl analogs of 4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5356898-A | Antiinflammatory agents, antiallergens, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1992013844-A1 | SUBSTITUTED 4,6-DI-TERTIARY-BUTYL-5-HYDROXY-PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1992-08-20 | — | — | WO | disclosed |