Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694570 | 0.74 | PTGS2 (1.00) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8495448 | 0.73 | ALOX5 (0.65) | PTGS1PTGS2ALOX5GAALMNA | |
| SCHEMBL9182983 | 0.72 | PTGS2 (0.97) | PTGS1PTGS2ALOX5 | |
| SCHEMBL9731459 | 0.71 | PTGS1 (0.57) | PTGS1PTGS2ALOX5GAALMNA | |
| SCHEMBL9456770 | 0.71 | ALOX5 (0.55) | PTGS1PTGS2ALOX5GAALMNA | |
| SCHEMBL14594123 | 0.71 | ALOX5 (0.68) | PTGS1PTGS2ALOX5GAALMNA | |
| SCHEMBL9731249 | 0.70 | PTGS2 (0.59) | PTGS1PTGS2ALOX5 | |
| SCHEMBL9731381 | 0.70 | PTGS2 (0.59) | PTGS1PTGS2ALOX5GAA | |
| SCHEMBL9731929 | 0.69 | PTGS2 (0.58) | PTGS1PTGS2ALOX5GAALMNA | |
| SCHEMBL9177866 | 0.69 | PTGS1 (0.62) | PTGS1PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449211-A1 | 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | claimed |
| US-5102897-A | Antiinflammatory, antiarthritic, antiulcer or antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1992-04-07 | — | — | US | disclosed |
| EP-0449211-A1 | 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |