Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117982 | 0.89 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL9117719 | 0.88 | PTGS2 (0.56) | PTGS2PTGS1S1PR1 | |
| SCHEMBL9118462 | 0.88 | PTGS2 (0.56) | PTGS2PTGS1SMN1; SMN2ERAP1SCN9A | |
| SCHEMBL9116418 | 0.87 | PTGS2 (0.60) | PTGS2PTGS1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL9115376 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1ALOX15 | |
| SCHEMBL9117655 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL9118082 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1SMN1; SMN2GAALMNA | |
| SCHEMBL9117792 | 0.84 | PTGS2 (0.77) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9116870 | 0.84 | PTGS2 (0.44) | PTGS2PTGS1EPAS1ALOX15 | |
| SCHEMBL9117202 | 0.84 | PTGS2 (0.47) | PTGS2PTGS1ERAP1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |