Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.47 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.32 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115376 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1KIF11 | |
| SCHEMBL9116870 | 0.88 | PTGS2 (0.44) | PTGS2PTGS1KIF11EPAS1 | |
| SCHEMBL9117131 | 0.87 | PTGS2 (0.46) | PTGS2PTGS1MAPTLMNA | |
| SCHEMBL9117493 | 0.86 | PTGS2 (0.48) | PTGS2PTGS1KIF11ERAP1SLC22A12 | |
| SCHEMBL9118944 | 0.86 | PTGS2 (0.65) | PTGS2PTGS1KIF11 | |
| SCHEMBL9116462 | 0.86 | KIF11 (0.52) | PTGS2PTGS1KIF11 | |
| SCHEMBL9117649 | 0.86 | PTGS2 (0.52) | PTGS2PTGS1EPAS1 | |
| SCHEMBL9117809 | 0.84 | PTGS2 (0.46) | PTGS2PTGS1KIF11ERAP1SLC22A12 | |
| SCHEMBL9119852 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1ERAP1LMNATP53 | |
| SCHEMBL9117096 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |