Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121128 | 0.84 | TSHR (0.71) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL16178460 | 0.84 | TSHR (0.43) | TSHRNPSR1KDM4EGAACACNA1B | |
| SCHEMBL11753470 | 0.84 | CACNA1B (0.55) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL16178523 | 0.82 | KDM4E (0.66) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL16178473 | 0.81 | MET (0.49) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL16178557 | 0.81 | TSHR (0.50) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL8699921 | 0.80 | CACNA1B (0.65) | KMT2ACACNA1B | |
| SCHEMBL10656803 | 0.77 | CACNA1F (0.53) | TSHRNPSR1KMT2ACACNA1BLMNA | |
| SCHEMBL11750748 | 0.77 | KDM4E (0.53) | TSHRNPSR1KDM4EGAAKMT2A | |
| SCHEMBL9363842 | 0.75 | KMT2A (0.47) | TSHRNPSR1KMT2ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432185-A | Treating patients exhibiting acute or chronic ischaemic disorders associated with disorders of microcirculation, without lowering or increasing blood pressure | BAYER AKTIENGESELLSCHAFT (DE) | 1995-07-11 | — | — | US | disclosed |
| US-5234935-A | Preventing myocardial infarct | BAYER AKTIENGESELLSCHAFT (DE) | 1993-08-10 | — | — | US | disclosed |