Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 14/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 8/20 | 0.43 |
| ▸ | RARG | P13631 | 8/20 | 0.43 |
| ▸ | RXRB | P28702 | 8/20 | 0.43 |
| ▸ | RXRG | P48443 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26970060 | 0.78 | RARA (0.62) | RARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9430374 | 0.76 | RARB (0.41) | RARACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7621921 | 0.75 | RXRA (0.39) | RARACYP3A4RXRARARBRARG | |
| SCHEMBL7617142 | 0.75 | RXRA (0.39) | RARACYP3A4RXRARARBRARG | |
| SCHEMBL7621926 | 0.71 | RXRA (0.36) | RARACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9551762 | 0.71 | RARB (0.42) | RARACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28646163 | 0.70 | RXRA (0.59) | RARARXRARARBRARGRXRB | |
| SCHEMBL7879971 | 0.69 | TP53 (0.42) | RARACYP1A2RXRATP53RARB | |
| SCHEMBL32690872 | 0.69 | TSHR (0.61) | CYP1A2CYP3A4TP53TSHR | |
| SCHEMBL217628 | 0.69 | TSHR (0.61) | CYP1A2CYP3A4TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428052-A | Classifiable as retinoids; skin disorders, corneopathy | CENTRE INTERNATIONALE DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1995-06-27 | — | — | US | disclosed |
| US-5420145-A | Antileukemia | Shudo, Koichi (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0617020-A1 | Carboxylic acid derivatives having retinoic acid-like activity | Shudo, Koichi, Prof. Dr. (JP) | 1994-09-28 | — | — | EP | disclosed |
| US-5288744-A | Tetramethyltetrahydronaphthyl benzothiazole for treating skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1994-02-22 | — | — | US | disclosed |
| US-5260295-A | Retinoic acid derivatives, cosmetics, skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5059621-A | Treatment of dermatologic ailments linked to keratinization disorder | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1991-10-22 | — | — | US | disclosed |
| US-4920140-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-04-24 | — | — | US | disclosed |
| US-4740519-A | Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1988-04-26 | — | — | US | disclosed |