Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.82 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.82 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alpha-Ketoglutaric Acid SCHEMBL27892915 | 0.97 | EGLN1 (0.78) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| SCHEMBL27768 | 0.91 | SLC22A6 (0.69) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL30208560 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL29783374 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL30029036 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL17127347 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL3776640 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL932116 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Alpha-Ketoglutaric Acid SCHEMBL7400 | 0.91 | EGLN1 (1.00) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 | |
| Water SCHEMBL715450 | 0.88 | SLC22A6 (0.65) | EGLN1MAPK1SLC13A3OR51E2SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105815313-B | Vegetable heavy metal blocking agent and use method thereof | 华南农业大学 | 2018-07-20 | — | — | CN | claimed |
| WO-2011050211-A2 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| EP-1778616-A1 | ALPHA-KETOGLUTARATES AND THEIR USE AS THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006016828-A2 | USE OF ALPHA KETOGLUTARATE FOR TREATING ALZHEIMER, PARKINSON | SGP & SONS AB (SE) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006016143-A1 | ALPHA-KETOGLUTARATES AND THEIR USE AS THERAPEUTIC AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |