Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | CTSE | P14091 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709645 | 0.83 | REN (0.58) | REN | |
| SCHEMBL7272241 | 0.83 | REN (0.58) | REN | |
| SCHEMBL7266599 | 0.83 | REN (0.58) | REN | |
| SCHEMBL6696371 | 0.83 | REN (0.58) | REN | |
| SCHEMBL7395966 | 0.77 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL7281729 | 0.76 | REN (0.56) | RENCA1CA2CA7CTSD | |
| SCHEMBL7350020 | 0.74 | REN (0.61) | REN | |
| SCHEMBL7271038 | 0.73 | REN (0.51) | RENCTSDCTSE | |
| SCHEMBL7355086 | 0.72 | REN (0.54) | RENCTSDCTSE | |
| SCHEMBL9435421 | 0.72 | REN (0.54) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5442044-A | Hypotensive agents | PFIZER INC. (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0661292-A1 | Orally active renin inhibitors | PFIZER INC. (US) | 1995-07-05 | — | — | EP | disclosed |