Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.62 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TOP2A | P11388 | 2/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28431272 | 0.82 | KDM4E (0.62) | NPC1RAB9AL3MBTL1GAAMAPT | |
| SCHEMBL12720817 | 0.79 | NPC1 (0.76) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL30454796 | 0.79 | TOP2A (0.68) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL9120443 | 0.78 | TOP2A (0.60) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL12218079 | 0.77 | AGTR1 (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL30826082 | 0.77 | AGTR1 (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL15882844 | 0.77 | AGTR1 (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL17438145 | 0.77 | AGTR1 (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL29883013 | 0.76 | TOP2A (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 | |
| SCHEMBL17987719 | 0.76 | TOP2A (1.00) | AGTR1NPC1RAB9AOPRK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393883-A | Ribonucleotide reductase inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-02-28 | — | — | US | disclosed |
| US-5175165-A | Acyclovir and a thiocarbonohydrazone ribonucleotide reductase inhibitor for treatment of herpes virus | BURROUGHS WELLCOME CO. (US) | 1992-12-29 | — | — | US | disclosed |
| EP-0349243-B1 | ANTIVIRAL COMBINATIONS AND COMPOUNDS THEREFOR | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-01 | — | — | EP | disclosed |
| EP-0349243-A2 | Antiviral combinations and compounds therefor | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-01-03 | — | — | EP | disclosed |