Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123690 | 1.00 | FOLH1 (0.51) | FOLH1ACEHTTMMP2MMP9 | |
| SCHEMBL10772948 | 0.92 | CA1 (0.49) | FOLH1ACEHTTMMP3TGM2 | |
| SCHEMBL10910712 | 0.88 | PTGER4 (0.51) | FOLH1MMP2MMP9MMP3 | |
| SCHEMBL10910064 | 0.83 | ACE (0.49) | ACE | |
| SCHEMBL10910070 | 0.83 | ACE (0.49) | ACE | |
| SCHEMBL10930131 | 0.82 | MMP3 (0.60) | FOLH1HTTMMP2MMP9MMP3 | |
| SCHEMBL10453110 | 0.82 | ACE (0.73) | ACE | |
| SCHEMBL9353134 | 0.82 | ACE (0.73) | ACE | |
| SCHEMBL9353151 | 0.81 | ACE (0.43) | ACEDPP8DPP7 | |
| SCHEMBL10910736 | 0.81 | ACE (0.74) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436245-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0414190-A2 | Phosphonate substituted amino or imino acids useful as antihypertensives | E.R. SQUIBB & SONS, INC. (US) | 1991-02-27 | — | — | EP | disclosed |
| US-4616005-A | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives | E. R. SQUIBB & SONS, INC. (US) | 1986-10-07 | — | — | US | disclosed |