Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2625524 | 0.98 | SMN1; SMN2 (0.55) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL2625523 | 0.94 | SMN1; SMN2 (0.50) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL23518502 | 0.90 | HSD11B1 (0.54) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL23518575 | 0.90 | HSD11B1 (0.54) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL1515374 | 0.90 | HSD11B1 (0.54) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL23518549 | 0.86 | HSD11B1 (0.45) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL14748208 | 0.86 | HPGD (0.55) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL12572628 | 0.84 | SMN1; SMN2 (0.53) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL12384376 | 0.82 | EPHX2 (0.52) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL16543099 | 0.82 | HSD11B1 (0.49) | HPGDNPSR1EPHX1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| EP-3141252-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9199996-B2 | Pyrido[4,3-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-20130190344-A1 | PYRIDO[4,3-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20130190308-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-25 | — | — | US | disclosed |
| US-20130184303-A1 | PYRIDO[4,3-B]INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2013-07-18 | — | — | US | disclosed |
| US-5434190-A | N-aryl and N-cycloalkyl neoalkanamide insect repellents | COLGATE-PALMOLIVE CO. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0499992-B1 | N-Aryl and N-cycloalkyl neoalkanamide insect repellents | COLGATE PALMOLIVE CO (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5182305-A | N-ARYL AND N-CYCLOAKYL NEOALKANAMIDE INSECT REPELLENTS | COLGATE-PALMOLIVE CO. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0499992-A1 | N-Aryl and N-cycloalkyl neoalkanamide insect repellents | Colgate-Palmolive Company (US) | 1992-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190344-A1 | PYRIDO[4,3-B]INDOLES AND METHODS OF USE | HTR3B, HTR4, HTR2C | HPGD 319/4885NPSR1 113/4885EPHX1 393/4885 |
| US-20130190308-A1 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE | HTR3B, HTR4, HTR2C | HPGD 325/4885NPSR1 115/4885EPHX1 393/4885 |
| US-20130184303-A1 | PYRIDO[4,3-B]INDOLES AND METHODS OF USE | HTR3B, HTR4, HTR2C | HPGD 319/4885NPSR1 113/4885EPHX1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.