Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | DCPS | Q96C86 | 3/20 | 0.35 |
| ▸ | DHFR | P00374 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123661 | 0.85 | LTA4H (0.55) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL488298 | 0.85 | LTA4H (0.58) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL3019351 | 0.84 | LTA4H (0.54) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL9127353 | 0.82 | MAPK14 (0.55) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL488397 | 0.80 | LTA4H (0.53) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL6079578 | 0.79 | LTA4H (0.75) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL488813 | 0.79 | RAB9A (0.55) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL488951 | 0.78 | NPC1 (0.61) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL9747086 | 0.78 | LTA4H (0.58) | LTA4HMAPK14NPC1RAB9AHTT | |
| SCHEMBL6079764 | 0.78 | LTA4H (0.54) | LTA4HMAPK14NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |