Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125404 | 0.87 | HPGD (0.59) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL14112017 | 0.84 | KMT2A (0.65) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL9124718 | 0.83 | ESR1 (0.55) | HPGDSMN1; SMN2MAPTALDH1A1RECQL | |
| SCHEMBL7527675 | 0.83 | MAPT (0.64) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL11613615 | 0.81 | KMT2A (0.61) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL1185097 | 0.80 | GAA (0.66) | KMT2AHPGDGAARAB9AMEN1 | |
| SCHEMBL2719871 | 0.79 | KMT2A (0.67) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL14075079 | 0.78 | HPGD (0.62) | KMT2AHPGDGAASMN1; SMN2RAB9A | |
| SCHEMBL5272168 | 0.77 | KMT2A (1.00) | KMT2AHPGDSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3087061 | 0.77 | GAA (0.73) | KMT2AHPGDGAARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476848-A | Antihistamines | SANKYO COMPANY, LIMITED (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5461051-A | Tetracyclic compounds having anti-allergic and anti-asthmatic activities and their use | SANKYO COMPANY, LIMITED (JP) | 1995-10-24 | — | — | US | disclosed |
| US-5362725-A | Antiallergens, antiasthmatic | SANKYO COMPANY, LIMITED (JP) | 1994-11-08 | — | — | US | disclosed |
| EP-0505014-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1992-09-23 | — | — | EP | disclosed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | disclosed |