Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.61 |
| ▸ | GRM5 | P41594 | 10/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124591 | 1.00 | ALOX5 (0.61) | ALOX5GRM5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9124587 | 1.00 | ALOX5 (0.61) | ALOX5GRM5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9125850 | 0.88 | ALOX5 (0.49) | ALOX5GRM5CYP1A2 | |
| SCHEMBL9218764 | 0.81 | ALOX5 (0.67) | ALOX5GRM5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9123685 | 0.77 | SLC6A4 (0.47) | ALOX5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9123689 | 0.77 | SLC6A4 (0.47) | ALOX5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9123695 | 0.77 | SLC6A4 (0.47) | ALOX5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9213851 | 0.76 | ALOX5 (1.00) | ALOX5GRM5 | |
| SCHEMBL9356426 | 0.75 | ALOX5 (0.41) | ALOX5GRM5SLC6A4SLC6A2OPRM1 | |
| SCHEMBL9352785 | 0.74 | ALOX5 (0.44) | ALOX5GRM5SLC6A4SLC6A2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385663-B1 | Heterocyclic cycloalkanes as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | claimed |
| US-5350754-A | Heterocyclic cycloalkanes | ZENECA LIMITED (GB) | 1994-09-27 | — | — | US | claimed |
| EP-0385663-B1 | Heterocyclic cycloalkanes as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | disclosed |
| US-5446043-A | Antiallergens, antiinflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-29 | — | — | US | disclosed |
| US-5350754-A | Heterocyclic cycloalkanes | ZENECA LIMITED (GB) | 1994-09-27 | — | — | US | disclosed |
| US-5217977-A | Lipoxygenase inhibitor for treating diseases medicated by leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |