Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.67 |
| ▸ | GRM5 | P41594 | 11/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9124587 | 0.81 | ALOX5 (0.61) | ALOX5GRM5ADAM17SLC6A4SLC6A2 | |
| SCHEMBL9124584 | 0.81 | ALOX5 (0.61) | ALOX5GRM5ADAM17SLC6A4SLC6A2 | |
| SCHEMBL9124591 | 0.81 | ALOX5 (0.61) | ALOX5GRM5ADAM17SLC6A4SLC6A2 | |
| SCHEMBL9213851 | 0.80 | ALOX5 (1.00) | ALOX5GRM5 | |
| SCHEMBL9224569 | 0.76 | ALOX5 (0.48) | ALOX5GRM5 | |
| SCHEMBL9224997 | 0.73 | ALOX5 (0.64) | ALOX5ADAM17 | |
| SCHEMBL5698315 | 0.73 | GRM5 (1.00) | ALOX5GRM5 | |
| SCHEMBL9022255 | 0.71 | ALOX5 (0.58) | ALOX5GRM5ADAM17 | |
| SCHEMBL9215709 | 0.70 | ALOX5 (0.77) | ALOX5GRM5 | |
| SCHEMBL9125850 | 0.69 | ALOX5 (0.49) | ALOX5GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385662-B1 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-13 | — | — | EP | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |