Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.67 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917467 | 0.92 | RIPK1 (0.62) | RIPK1PKN1PKN2PARP1CHEK1 | |
| SCHEMBL2845527 | 0.88 | RIPK1 (0.58) | RIPK1PKN1PKN2PARP1CHEK1 | |
| SCHEMBL9756381 | 0.85 | KDM4E (0.51) | RIPK1PARP1 | |
| SCHEMBL7478397 | 0.84 | PKN1 (0.59) | RIPK1PKN1PKN2PARP1ALDH1A1 | |
| SCHEMBL12730392 | 0.83 | PKN1 (0.57) | RIPK1PKN1PKN2PARP1CHEK1 | |
| SCHEMBL6841804 | 0.83 | PKN1 (0.57) | RIPK1PKN1PKN2PARP1ALDH1A1 | |
| SCHEMBL15767242 | 0.83 | PKN1 (0.57) | RIPK1PKN1PKN2 | |
| SCHEMBL28263632 | 0.82 | KDM4E (0.50) | RIPK1PARP1 | |
| SCHEMBL939723 | 0.82 | RIPK1 (0.59) | RIPK1PKN1PKN2PARP1ALDH1A1 | |
| SCHEMBL461964 | 0.81 | PARP1 (0.58) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470867-A | Imidazoles and their salts having antagonistic activity to angiotesin II recetors | ROUSSEL-UCLAF (FR) | 1995-11-28 | — | — | US | disclosed |
| EP-0425921-B1 | Benzimidazole derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5389634-A | Treating arterial hypertension, relaxing uterus, prevention of post-angioplastic restenosis | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5338756-A | Angiotensin II receptor antagonists | ROUSSEL UCLAF (FR) | 1994-08-16 | — | — | US | disclosed |
| US-5250554-A | Cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| US-5128356-A | Angiotensin antagonist; cardiovascular disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| EP-0425921-A1 | Benzimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-05-08 | — | — | EP | disclosed |