Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 8/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | BRS3 | P32247 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28263632 | 0.96 | KDM4E (0.50) | KDM4EHPGDDHODHPARP1RIPK1 | |
| SCHEMBL9224298 | 0.92 | KDM4E (0.54) | KDM4EHPGDDHODHPARP1RIPK1 | |
| SCHEMBL15808131 | 0.85 | KDM4E (0.56) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL9125563 | 0.85 | RIPK1 (0.67) | PARP1RIPK1 | |
| SCHEMBL461964 | 0.84 | PARP1 (0.58) | PARP1 | |
| SCHEMBL6948954 | 0.82 | NPC1 (0.55) | KDM4EHPGDDHODHPARP1BRS3 | |
| SCHEMBL4260461 | 0.81 | KDM4E (0.57) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL3245583 | 0.80 | PDE10A (0.54) | PARP1 | |
| SCHEMBL6841606 | 0.80 | KDM4E (0.56) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL9304542 | 0.79 | BRS3 (0.56) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461040-A1 | Imidazol derivatives, their process for production, intermediates, their application as medicaments and the pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1991-12-11 | — | — | EP | disclosed |