Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080485 | 0.85 | MAPK14 (0.54) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL6079375 | 0.79 | LTA4H (0.61) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL9125665 | 0.77 | NPC1 (1.00) | NPC1RAB9ACSF1RLTA4HMAPK14 | |
| SCHEMBL9115564 | 0.77 | NPC1 (0.72) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL6080009 | 0.76 | NPC1 (0.61) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL488182 | 0.74 | RAB9A (0.58) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL13529594 | 0.74 | CSF1R (0.44) | NPC1RAB9ACSF1RCHRNA7USP7 | |
| SCHEMBL6079764 | 0.73 | LTA4H (0.54) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL9127353 | 0.72 | MAPK14 (0.55) | NPC1RAB9ALTA4HMAPK14MAPT | |
| SCHEMBL9126648 | 0.71 | LTA4H (0.51) | NPC1RAB9ALTA4HMAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |