Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64943 | 0.95 | REN (0.45) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL78705 | 0.90 | REN (0.47) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL78704 | 0.90 | REN (0.47) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL65406 | 0.83 | REN (0.49) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL78618 | 0.72 | SLC6A4 (0.51) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL66535 | 0.67 | SLC6A4 (0.52) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL79378 | 0.67 | SLC6A4 (0.64) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL65431 | 0.67 | REN (0.49) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL65432 | 0.67 | REN (0.49) | RENSLC6A4SLC6A2KCNH2CYP3A4 | |
| SCHEMBL5072329 | 0.66 | SLC6A4 (0.59) | RENSLC6A4SLC6A2KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |