Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594393 | 0.86 | KMT2A (0.41) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL9128692 | 0.86 | KMT2A (0.41) | NPC1RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL3113521 | 0.84 | DRD2 (0.41) | NPC1RAB9ASMN1; SMN2TTRMAPT | |
| SCHEMBL26491007 | 0.83 | DRD2 (0.43) | NPC1RAB9ATTRHSD17B10DRD2 | |
| SCHEMBL6314028 | 0.82 | DRD2 (0.38) | SMN1; SMN2DRD2MRGPRX4CSNK2A1RXRA | |
| SCHEMBL5678686 | 0.81 | DRD2 (0.46) | HSD17B10DRD2MRGPRX4POLBRXRA | |
| SCHEMBL7262108 | 0.81 | DRD2 (0.39) | NPC1RAB9ATTRTP53DRD2 | |
| SCHEMBL3119147 | 0.81 | DRD2 (0.56) | NPC1RAB9ASMN1; SMN2TTRHTT | |
| SCHEMBL499011 | 0.81 | DRD2 (0.50) | NPC1RAB9ASMN1; SMN2TTRHTT | |
| SCHEMBL16901976 | 0.80 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449682-A | Angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5374638-A | Cardiovascular disorders, hypotensive agents | MERCK & CO., INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5240938-A | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring | MERCK & CO., INC. (US) | 1993-08-31 | — | — | US | disclosed |